Volume 24, Issue 103, May - June, 2020

A study on the effect of adropin on blood pressure in male albino rats

Mohamad Y.R. Yosof^1,3♦, Husam M. Edrees^1,2

¹Medical Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
²College of Public Health and Health Informatics, Qassim University, Saudi Arabia; Email address: husam_qu@hotmail.com
³Basic Medical Sciences Department, Unaizah College of Medicine and Medical sciences, Qassim University, Saudi Arabia

^♦Corresponding author
Medical Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt / Basic Medical Sciences Department, Unaizah College of Medicine and Medical sciences, Qassim University, Saudi Arabia; Email: myr777777777@yahoo.com

ABSTRACT

Adropin is a peptide hormone involved in insulin sensitivity and cardiac function. The relationship of adropin and vascular functions is still in controversy, no available data demonstrated the effect of adropin on blood pressure. Objective: Demonstrating the effect of adropin on blood pressure in normal and induced hypertensive rats. 48 male albino rats were divided into 6 groups: Control (C), Adropin treated (AT), Uninephrectomized (UNX), UNX-adropin treated (UNX+A), DOCA salt hypertensive (DOCA) and DOCA saltadropin treated (DOCA+A). Adropin reduced significantly systolic and diastolic pressures in both UNX+A group in comparison with UNX one (P≤ 0.0001) and in DOCA+A group (P≤ 0.0001) in comparison with DOCA group. Diastolic pressure was decreased significantly in adropin treated group (P≤ 0.05) in comparison with control group. Conclusion: According to available resources, this study is the first investigating the direct effect of adropin on blood pressure. Adropin decreased significantly diastolic pressure in both normal and induced hypertensive rats but reduced significantly systolic pressure only in hypertensive rats. Adropin might be a therapeutic agent in treatment of hypertension however, further studies on human are recommended.

Keywords: adropin, blood pressure, vascular, hypertensive, DOCA

Medical Science, 2020, 24(103), 1700-1707

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