Volume 24, Issue 103, May - June, 2020

Clinical characteristics of candidemia among neonates in a Children’s Hospital in Vietnam: A retrospective study

Xuan Minh Ngo^♦, Diem Thi Ngoc Nguyen

Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh city, Vietnam

^♦Corresponding author
Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam; Email: xuanlien62@pnt.edu.vn

ABSTRACT

Objectives: This study examined the prevalence, pathogenic characteristics, and clinical of neonatal candidemia as well as outcomes of disease treatment. Methods: This retrospective study was conducted from 2014 to 2019 on 90 neonates diagnosed with candidemia in Vietnam. Results: The cases infected with non-albicans Candida (NAC) species exceeded those infected with C. albicans (72.2% vs. 27.8%). Of the latter, 87.7% were born preterm, and 80% were of low birth weights. Risk factors included the administration of two antibiotics or more (97.8%), the administration of parenteral nutrition (90%), the insertion of central venous catheters (67.8%), endotracheal intubation (55.6%), the dispensation of parenteral nutrition with lipids (38.9%), abdominal operations (28.9%), and the use of H2 inhibitors (15.5%). All the neonates were sensitive to amphotericin B, and 92.3% were sensitive to fluconazole. All the fluconazole-resistant cases belonged to the NAC group. The mortality rate from Candida septicemia was 26.7%, with the rate involving C. albicans being higher (41.7%) than that occurring in the NAC group. Conclusion: NAC species have been dominant pathogens, which develop resistance to anti-fungal agents and whose prevalence increases over time.

Keywords: Candidemia, Neonate, Risk factors, Vietnam

Medical Science, 2020, 24(103), 1780-1788

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