Volume 62, Issue 342, September - December 2026

Influence of Allium sativum on the hematology, serum chemistry, and oxidative stability biomarkers of West African Dwarf goats artificially infected with Haemonchus contortus

Micheal Taiwo Ayankoso^1♦, Olusiji Sunday Sowande², Azeez Olanrewaju Yusuf², Kafayat Omowumi Adebayo³, Ayobami John Owolabi², Taiwo Olufemi Ajayi²

¹Department of Animal Science, Faculty of Agriculture, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria.
²Department of Animal Production and Health, Federal University of Agriculture, Abeokuta, Nigeria.
³Department of Animal Nutrition, Federal University of Agriculture, Abeokuta, Nigeria.

^♦Corresponding Author
Micheal Taiwo Ayankoso, Department of Animal Science, Faculty of Agriculture, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria

ABSTRACT

This study was conducted to access the influence of Allium sativum extract on the hematology, serum chemistry and oxidative stability markers of West African Dwarf goats experimentally infected with Haemonchus contortus. Twenty-five growing WAD goats were used for the study. These animals were divided into five treatment groups, comprising of five animals each in a completely randomized design. Treatments comprised A. sativum extract at 7.5, 12.5, and 17.5 mg/mL, albendazole at 10 mg/mL, and water as positive and negative controls, respectively. The experiment lasted 56 days. Collection of blood samples was done at the commencement and termination of the study. The hematological indices, serum chemistry and oxidative stability biomarkers of the animals were determined. The data gathered were analyzed using one-way analysis of variance, and treatment means were separated using Tukey’s significant difference test at P < 0.05. At the end of the experiment, A. sativum significantly affected packed cell volume, red blood cell count, hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin. The 12.5 mg/mL treatment recorded a PCV of 32.13% and the highest hemoglobin concentration of 11.20 g/dL, whereas 17.5 mg/mL produced a PCV of 32.63%, MCV of 22.40 fL, and MCH of 7.89 pg. Significant effects were also observed for serum total protein, globulin, cholesterol, urea, and alkaline phosphatase. Total protein and globulin were highest at 7.5 mg/mL, with values of 9.35 and 4.09 g/dL, respectively. The urea level decreased gradually as the extract concentration increases, till it reached 25.00 mg/dL in group treated with 17.5 mg/mL of the extract. Glutathione peroxidase activity at the onset was higher at 12.5 and 17.5 mg/mL, with values of 16.55 and 17.80 U/L, respectively. The total bilirubin obtained after the treatment reduced from 0.63 mg/dL in group treated with water to 0.18 mg/dL in group treated with 17.5 mg/mL of the extract. In conclusion, group treated with 12.5 mg/mL of the extract, produced the most favorable physiological and parasite-related responses. The outcomes further confirm the use of A. sativum extract as a potential complementary intervention for the treatment of H. contortus infection in West African Dwarf goats.

Keywords: Allium sativum; anthelmintic activity; West African Dwarf goats; serum chemistry; oxidative biomakers; hematology

Discovery, 2026, 62, e31d3330

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Published: 18 October 2026