Background: During COVID-19, the majority of the globe nations have experienced horrible difficult times during the COVID -19
outbreak. Thus, the present study aimed to assess the association between socio-demographical characteristics, comorbidities and
anxiety burden during COVID-19 lockdown in Saudi Arabia. Methodology: In the present descriptive survey, 422 persons (living in the
City of Ha'il, Northern Saudi Arabia) were recruited. Both Saudi and non-Saudi persons were included during the COVID-19
lockdown (May 2020). The study was designed to assess the Psychological influence of the COVID-19 outbreak on the community of
northern Saudi Arabia. Results: Approximately, 84% of the study population was found with some sorts of anxiety. About
206/257(80%) of the males have claimed some sorts of the anxiety of whom 118/206(57%) were found with anxiety level ≥5. About
150/165(91%) of the females have claimed some sorts of the anxiety of whom 102/150(68%) were found with anxiety level ≥5. The
risk of anxiety associated with female gender and the relative risk (RR) the 95% confidence interval (95% CI); RR (95% CI) =
0.4581(0.2666 to 0.7873), P = 0.0047, z -statistic = 2.826. Higher levels of anxiety (level ≥5) were detected in 178/336(53%) Saudi and
42/86(49%) of the non-Saudi participants. The risk of anxiety associated with Saudi participant, RR (95% CI) = 0.8702
(0.5149 to 1.4707), P = 0.6036, z statistic = 0.519. Conclusion: Sociodemographic characteristics (especially, gender, job status, and
age) are important factors affecting the community during an epidemic crisis, and should be considered by health policymakers.
Especial psychologic support is deemed important for patients with chronic comorbidities, particularly hypertensive patients and
those with respiratory and cardiovascular diseases.
Keywords: COVID-19, anxiety, comorbidities, Saudi Arabia, Sociodemographic